Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

371
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
371
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.0K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.0K
Theoretical Foundations of Nursing Practice01:30

Theoretical Foundations of Nursing Practice

17.4K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.4K
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

843
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
843
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

520
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
520
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

421
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
421

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Retinol Levels in Patients with Cardiac Surgery-Associated Acute Kidney Injury-A Prospective Single-Center Exploratory Study.

Nutrients·2026
Same author

Environmental Exposure and Long-Term Mortality After Coronary Artery Bypass Grafting: A Multicenter Cohort Study Beyond Traditional Risk Factors.

Toxics·2026
Same author

Therapeutic impact of normal dietary patterns on diabetic cardiomyopathy: Transcriptomic and proteomic insights.

Journal of molecular and cellular cardiology·2026
Same author

Interplay between parathyroid hormone concentration and valvular and aortic calcifications.

Archives of medical science : AMS·2026
Same author

Winter Temperature and Long-Term Mortality After Coronary Artery Bypass Grafting: A Multicenter Cohort Study.

Journal of clinical medicine·2026
Same author

Characteristics of patients qualified for aortic valve replacement combined with coronary artery bypass grafting surgery in the era of transcatheter aortic valve implantation dominance study (CAPTOR study).

Journal of thoracic disease·2026

Related Experiment Video

Updated: Jan 29, 2026

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models
08:34

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models

Published on: May 14, 2014

12.6K

A Control-Theoretic Model of Atherosclerosis.

Dorota Formanowicz1, Jacek B Krawczyk2, Bartłomiej Perek3

  • 1Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland. doforman@ump.edu.pl.

International Journal of Molecular Sciences
|February 15, 2019
PubMed
Summary

This study introduces a mathematical model to track atherosclerosis plaque growth, showing how statins can manage inflammation and reduce cardiovascular risk without invasive scans.

Keywords:
atherosclerosiscontrol-theoretic modellogistic growthstatins

More Related Videos

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.3K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.4K

Related Experiment Videos

Last Updated: Jan 29, 2026

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models
08:34

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models

Published on: May 14, 2014

12.6K
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.3K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.4K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Disease Research
  • Mathematical Modeling

Background:

  • Atherosclerosis is a chronic inflammatory arterial disease characterized by plaque buildup.
  • Understanding plaque progression and the efficacy of treatments like statins is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To develop a control-theoretic aggregate model for atherosclerosis plaque progression.
  • To investigate the role of inflammation and the impact of statins on plaque growth.
  • To assess patient-specific factors like age and health on disease progression and treatment response.

Main Methods:

  • Utilized a control-theoretic aggregate model incorporating a logistic function for constrained plaque growth.
  • Integrated the role of inflammation as a key driver of disease progression.
  • Modeled the effect of statins as a control mechanism for plaque progression.
  • Estimated model parameters using original data and calibrated with published research and clinical studies.

Main Results:

  • The model quantifies the impact of statins on plaque thickness and disease progression.
  • It demonstrates how patient age and overall health influence plaque growth and statin sensitivity.
  • The model provides a non-invasive method to estimate treatment effects and cardiovascular risk.

Conclusions:

  • The developed model offers a valuable tool for understanding atherosclerosis plaque dynamics.
  • It highlights the potential of statins in controlling inflammation-driven plaque progression.
  • The model facilitates personalized risk assessment and treatment evaluation without the need for artery scans.