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Related Experiment Video

Updated: Jan 29, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
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KDM4B: A Nail for Every Hammer?

Cailin Wilson1, Adam J Krieg2,3

  • 1Department of Pathology, University of Kansas Medical Center, Kansas City, KS 66160, USA. cailin.wilson@gmail.com.

Genes
|February 15, 2019
PubMed
Summary
This summary is machine-generated.

Epigenetic regulators like KDM4B are crucial in cancer and development. This review explores KDM4B

Keywords:
KDM4Bcancerdevelopmenthistone demethylaseshypoxiaovary

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • Epigenetic modifications, particularly histone methylation, are fundamental to gene regulation in development and disease.
  • Histone demethylases, such as the KDM4 family, remove methyl marks (e.g., H3K9me3) that control chromatin structure and gene expression.
  • KDM4 enzymes are frequently overexpressed in various cancers, presenting them as potential therapeutic targets.

Purpose of the Study:

  • To review the known regulation of KDM4B in response to diverse cellular stimuli.
  • To discuss the biological implications of KDM4B's context-dependent expression in cancer and reproductive biology.

Main Methods:

  • Literature review of studies on KDM4B regulation and function.
  • Analysis of KDM4B's role in gene transcription, DNA repair, and chromatin remodeling.
  • Integration of findings related to KDM4B's response to DNA damage, hormones, and hypoxia.

Main Results:

  • KDM4B is regulated by multiple cellular signals, including DNA damage, steroid hormones, and hypoxia.
  • Its expression and activity are linked to heterochromatin maintenance and gene derepression.
  • Dysregulation of KDM4B contributes to cancer progression and impacts reproductive processes.

Conclusions:

  • KDM4B is a key epigenetic regulator whose expression is tightly controlled by the cellular environment.
  • Understanding KDM4B's context-specific roles is vital for developing targeted cancer therapies and for insights into reproductive health.
  • Further research into KDM4B regulation and function will illuminate its broader significance in human biology and disease.