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Dermal mesenchymal stem cells: a resource of migration-associated function in psoriasis?
Xuping Niu1, Junqing Li1, Xincheng Zhao1
1Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Centre Hospital, No. 1 Dong San Dao Xiang, Jiefang Road, Taiyuan, 030009, Shanxi Province, China.
Stem Cell Research & Therapy
|February 15, 2019
Summary
Dermal mesenchymal stem cells (DMSCs) from psoriasis patients show altered gene expression, potentially driving immune cell migration in this chronic inflammatory disease. These findings suggest DMSCs play a key role in psoriasis pathogenesis.
Area of Science:
- Immunology
- Dermatology
- Stem Cell Biology
Background:
- Psoriasis is a chronic, systemic, immune-mediated inflammatory disease.
- Mesenchymal stem cells modulate the inflammatory microenvironment by influencing immunocyte behavior.
Purpose of the Study:
- To investigate the role of dermal mesenchymal stem cells (DMSCs) in immune cell migration in psoriasis patients.
- To analyze the expression of migration-associated genes in DMSCs from psoriasis patients.
Main Methods:
- Recruited 22 psoriasis patients and 22 healthy controls.
- Analyzed seven migration-associated genes (CMKLR-1, COL8A-1, NETO-2, NRK, SFRP, SULF-2, SYTL-2) using qPCR and Western blot.
- Assessed peripheral blood-derived mononuclear cell (PBMC) migration to DMSCs using a Transwell chamber system.
Main Results:
- Upregulation of CMKLR-1, COL8A-1, NETO-2, NRK, SYTL-2, and SULF-2 mRNA and protein in psoriatic DMSCs.
- Significant downregulation of SFRP-2 in psoriatic DMSCs.
- Increased in vitro migration of normal PBMCs towards psoriatic DMSCs (6.3-fold increase).
Conclusions:
- DMSCs may be pathologically involved in monocyte migration in psoriasis.
- DMSCs might regulate immune responses and be central to the "psoriatic march."
- Altered gene expression in DMSCs contributes to psoriasis pathogenesis.
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