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Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Drug-Receptor Interactions01:29

Drug-Receptor Interactions

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Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
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Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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Factors Affecting Protein-Drug Binding: Drug Interactions01:23

Factors Affecting Protein-Drug Binding: Drug Interactions

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Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
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Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

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Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
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Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

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An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Optimizing Drug-Drug Interaction Alerts Using a Multidimensional Approach.

Calvin C Daniels1, Jonathan D Burlison2, Donald K Baker3

  • 1Pharmaceutical Sciences, calvin.daniels@stjude.org.

Pediatrics
|February 15, 2019
PubMed
Summary
This summary is machine-generated.

Excessive drug-drug interaction (DDI) alerts were reduced by 40% through a quality improvement initiative. This effort refined 47% of alerts, establishing a sustainable model for alert management.

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Area of Science:

  • Health Informatics
  • Clinical Decision Support Systems
  • Patient Safety

Background:

  • Excessive alerts from clinical decision support systems monitoring drug-drug interactions (DDIs) are a significant concern.
  • These interruptive alerts can decrease clinician efficiency and potentially impact patient care.

Purpose of the Study:

  • To reduce low-value, interruptive DDI alerts within a hospital setting.
  • To implement and evaluate a multidimensional quality improvement strategy for alert refinement.

Main Methods:

  • An interdisciplinary advisory group was established for oversight and expert input.
  • Alert data, categorized by drug class, were analyzed to identify and refine DDIs.
  • Refinement strategies included alert suppression and context-aware modifications.

Main Results:

  • 26 alert refinements were implemented, addressing 47% of all analyzed alerts.
  • Interruptive DDI alerts decreased by 40% for all clinicians and 82% for attending physicians.
  • Two patient safety events related to alert refinements were reported.

Conclusions:

  • A quality improvement effort successfully refined 47% of DDI alerts.
  • Significant reductions in DDI alerts were achieved over a 54-week period.
  • A sustainable model for ongoing alert refinement was established.