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Updated: Jan 29, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
Published on: January 22, 2011
Neuro-oncology: Implications of the molecular era
Michael W Ruff1, Joon H Uhm2, Eduardo E Benarroch2
1From the Department of Neurology (M.W.R., J.U., E.B.) and Division of Medical Oncology (M.W.R., J.U.), Mayo Clinic, Rochester, MN. ruff.michael@mayo.edu.
Abstract:
The field of neuro-oncology has recently experienced a renaissance in the understanding of the molecular underpinnings and pathophysiology of glioma. Genetic markers have significant implications regarding treatment responsiveness and prognosis and are now the primary basis for classification. This article gives an updated understanding of the pathogenesis and mechanisms of resistance of glioma via discussion of 4 molecular and genetic markers: MGMT, IDH, 1p/19q, and TERT.
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