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Related Concept Videos

Decreasing Function01:27

Decreasing Function

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A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
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Related Experiment Video

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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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Two Strains of Lactobacilli Effectively Decrease the Colonization of VRE in a Mouse Model.

Xianping Li1, Liqiong Song1, Siyi Zhu1

  • 1State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention - Chinese Center for Disease Control and Prevention, Beijing, China.

Frontiers in Cellular and Infection Microbiology
|February 15, 2019
PubMed
Summary

Fecal microbiota transplantation (FMT) and Lactobacillus treatments effectively reduced vancomycin-resistant Enterococcus (VRE) gut colonization. Both interventions restored gut microbiota diversity and impacted bacterial composition in a VRE mouse model.

Keywords:
16S rRNALactobacillusRNA-seqVancomycin-resistant Enterococcusfecal microbiota transplantation

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A Murine Model of Group B Streptococcus Vaginal Colonization
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Area of Science:

  • Gastroenterology
  • Microbiology
  • Infectious Diseases

Background:

  • Vancomycin-resistant Enterococcus (VRE) infection presents a significant clinical management challenge with no current effective treatments.
  • Fecal microbiota transplantation (FMT) and probiotic interventions show promise for reducing pathogenic bacteria in the gastrointestinal tract.
  • No prior studies have investigated FMT or probiotics for VRE reduction.

Purpose of the Study:

  • To evaluate the efficacy of FMT and two Lactobacillus strains (Y74 and HT121) in reducing VRE colonization.
  • To analyze the impact of these interventions on gut microbiota diversity and composition.
  • To investigate the effects on host gene expression in the colon.

Main Methods:

  • A VRE-infection mouse model was utilized.
  • Mice were treated with FMT, Lactobacillus strains (Y74, HT121), or phosphate-buffered saline (PBS).
  • Fecal microbiota, colon mRNA expression, and RNA-sequencing were analyzed.

Main Results:

  • Both Lactobacillus strains and FMT significantly reduced VRE colonization.
  • FMT and Lactobacillus treatments accelerated the restoration of intestinal microbiota diversity compared to PBS.
  • Lactobacillus administration more rapidly normalized Firmicutes but less rapidly normalized Bacteroides compared to FMT.

Conclusions:

  • Fecal microbiota transplantation and Lactobacillus interventions are effective strategies for decreasing VRE gut colonization.
  • These treatments modulate gut microbiota composition and diversity.
  • Host defense gene expression was altered by both FMT and Lactobacillus treatments.