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Related Experiment Video

Updated: Jan 29, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Recent Progress in Time-Resolved Biosensing and Bioimaging Based on Lanthanide-Doped Nanoparticles.

Qinqin Ma1, Jie Wang1, Zhiheng Li1

  • 1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.

Small (Weinheim an Der Bergstrasse, Germany)
|February 15, 2019
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Summary

Lanthanide-doped nanoparticles offer superior luminescence for bioanalysis, overcoming interference with time-resolved methods. This review highlights their use in sensitive biosensing and bioimaging applications.

Keywords:
autofluorescencelanthanideslong lifetimenanoparticletime-resolved techniques

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Luminescent nanomaterials are crucial for bioanalysis due to optical properties.
  • Autofluorescence and light scattering hinder performance in complex biological samples.
  • Time-resolved luminescence overcomes interference by detecting long-lived signals.

Purpose of the Study:

  • To review advancements in lanthanide-doped nanoparticles.
  • To summarize their applications in time-resolved biosensing and bioimaging.
  • To discuss future challenges and perspectives.

Main Methods:

  • Utilizing lanthanide-doped nanoparticles with unique electronic configurations.
  • Employing time-resolved luminescence methodology for signal detection.
  • Summarizing recent developments and applications in literature.

Main Results:

  • Lanthanide-doped nanoparticles exhibit long luminescence lifetimes and sharp emission.
  • These nanoparticles enable high-sensitivity biosensing and high-contrast bioimaging.
  • Time-resolved detection effectively eliminates background noise.

Conclusions:

  • Lanthanide-doped nanoparticles are promising for advanced bioanalysis.
  • Time-resolved luminescence enhances their utility in complex biological systems.
  • Further research is needed to address current challenges and unlock full potential.