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Abnormal amygdala resting-state functional connectivity in primary dysmenorrhea.

Zhifu Shen1, Siyi Yu1, Minyu Wang2

  • 1Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine.

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Primary dysmenorrhea (PDM) patients exhibit altered amygdala functional connectivity (AFC) in brain networks. These changes, particularly in the default mode and reward systems, may link to pain mechanisms involving prostaglandin E2.

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Area of Science:

  • Neuroimaging
  • Pain Neuroscience
  • Clinical Neurology

Background:

  • Neuroimaging reveals functional brain abnormalities in primary dysmenorrhea (PDM) patients.
  • The specific alterations in the amygdala functional network within the pain matrix in PDM remain unclear.

Purpose of the Study:

  • To investigate intrinsic amygdala functional connectivity (AFC) network alterations in PDM patients during the ovulatory period.
  • To explore the clinical significance of abnormal AFC in PDM.

Main Methods:

  • Resting-state functional MRI (rs-fMRI) was used to construct AFC networks.
  • Thirty-six PDM patients and 35 healthy controls were analyzed.
  • Plasma prostaglandin E2 levels were measured during the ovulatory period.

Main Results:

  • PDM patients showed increased left AFC within the default mode network (medial prefrontal cortex, posterior cingulate cortex/precuneus, angular gyrus, inferior temporal gyrus).
  • Decreased left AFC was observed in the nucleus accumbens/orbital frontal cortex.
  • Reduced right AFC was found in the right orbital frontal cortex, insula, ventral tegmental area (VTA), left hippocampus, and insula.
  • Decreased right AFC in the VTA correlated with higher plasma prostaglandin E2 levels in PDM patients.

Conclusions:

  • The amygdala functional connectivity network is disrupted in PDM patients, affecting the default mode and reward systems.
  • Disrupted amygdala-VTA connectivity may contribute to prostaglandin-associated pathological mechanisms in PDM.