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Updated: Jan 29, 2026
08:55
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Multifocal Small Bowel Carcinoid: Evaluation by 68Ga-DOTATATE PET
Michael Clark1, Mark Nathan, Stephen M Broski
1From the Department of Radiology, Division of Nuclear Medicine, Mayo Clinic, Rochester, MN.
Clinical Nuclear Medicine
|February 15, 2019
Summary
Gallium-DOTATATE PET/CT imaging helps detect rare neuroendocrine tumors, specifically carcinoid tumors in the small bowel. This advanced imaging technique shows increased sensitivity for identifying multifocal carcinoid, improving diagnosis.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Carcinoid tumors are a rare subtype of neuroendocrine tumors.
- Neuroendocrine tumors express somatostatin receptor 2 (SSTR2).
- Ga-DOTATATE is a somatostatin analog targeting SSTR2 for imaging.
Observation:
- Two cases of primary multifocal small bowel carcinoid were evaluated.
- Ga-DOTATATE PET/CT imaging was used for visualization.
- Contrast-enhanced CT findings were used as a corollary.
Findings:
- Ga-DOTATATE PET/CT demonstrated high sensitivity in visualizing multifocal small bowel carcinoid.
- The imaging allowed for detailed assessment of tumor extent.
- Comparison with CT and In-octreotide scintigraphy highlighted superior sensitivity.
Implications:
- Ga-DOTATATE PET/CT is a valuable tool for diagnosing neuroendocrine tumors.
- Multifocal carcinoid tumors are expected to be increasingly recognized with this technology.
- Improved detection may lead to earlier intervention and better patient outcomes.
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