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Fluorescence Angiography for Evaluation of Aneurysm Perfusion and Parent Artery Patency in Rat and Rabbit Aneurysm Models
Published on: July 24, 2019
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Pharmacologic Management of Aneurysms.
Jan H Lindeman1, Jon S Matsumura2
1From the Department of Vascular Surgery, Leiden University Medical Center, the Netherlands (J.H.L.).
Circulation Research
|February 15, 2019
Summary
Medical therapy for aortic aneurysms shows promise in preclinical studies but lacks consistent clinical confirmation. Further research into better models and biomarkers is needed to advance treatment options.
Area of Science:
- Vascular Surgery
- Cardiovascular Medicine
- Pharmacology
Background:
- Current aortic aneurysm management relies on surgical repair.
- Medical therapies offer potential to halt or slow aneurysm progression, reducing surgical need.
- Preclinical studies suggest inflammatory and proteolytic pathways are key targets.
Purpose of the Study:
- To evaluate the potential of medical therapies for aortic aneurysm stabilization.
- To assess the feasibility of intervening in inflammatory and proteolytic cascades.
- To understand discrepancies between preclinical and clinical trial outcomes.
Main Methods:
- Review of preclinical studies on abdominal aortic aneurysm and Marfan syndrome models.
- Analysis of preoperative clinical intervention studies.
- Examination of clinical trial data on medical stabilization of aortic aneurysms.
Main Results:
- Preclinical studies identified numerous stabilization strategies.
- Clinical interventions targeting inflammatory and proteolytic pathways are feasible.
- Clinical studies show inconsistent results for medical stabilization of aortic aneurysms and Marfan syndrome aortopathy.
Conclusions:
- No medical therapy is currently recommended for aortic aneurysm stabilization.
- Discrepancies highlight limitations in current disease models and understanding.
- Improved preclinical models, biomarkers, and clinical trial designs are crucial for advancing medical therapies.
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