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The Innate Sense of Bacteriophages
Paul L Bollyky1, Patrick R Secor2
1Stanford University, Stanford, CA, USA.
Abstract:
Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsened inflammatory bowel disease pathogenesis.
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