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Related Experiment Video

Updated: Jan 29, 2026

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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Cathepsins: Potent regulators in carcinogenesis.

Tejinder Pal Khaket1, Taeg Kyu Kwon2, Sun Chul Kang1

  • 1Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Republic of Korea.

Pharmacology & Therapeutics
|February 15, 2019
PubMed
Summary

Cathepsins (CTS) are lysosomal enzymes crucial in cancer progression, influencing proliferation, invasion, and metastasis. Targeting CTS offers therapeutic potential by modulating these cancer-driving processes.

Keywords:
AngiogenesisCancerCathepsinsMetastasis: Drug resistance: Inhibitors

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Cathepsins (CTS) are lysosomal acid hydrolases implicated in various diseases.
  • These enzymes play a critical role in cancer progression by regulating key cellular processes.

Purpose of the Study:

  • To review the multifaceted roles of cathepsins in cancer signaling.
  • To discuss the therapeutic potential of targeting cathepsins for cancer treatment.

Main Methods:

  • Literature review focusing on cathepsin function in cancer.
  • Analysis of cathepsin involvement in cell proliferation, autophagy, angiogenesis, invasion, and metastasis.
  • Exploration of cathepsin's role in response to chemotherapy and radiotherapy.

Main Results:

  • Cathepsins regulate proteolytic cascades, protein turnover, and extracellular matrix degradation.
  • Extracellular cathepsins promote invasion and metastasis by facilitating angiogenesis.
  • Cathepsins influence cellular adaptation to cancer therapies, with potential for inducing cell death.

Conclusions:

  • Cathepsin's complex roles in cancer necessitate a detailed understanding for therapeutic strategies.
  • Targeting specific cathepsins presents a promising avenue for cancer therapy development.
  • Further research into cathepsin signaling pathways can yield significant insights into cancer biology.