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Aptamer-functionalized liposomes for targeted cancer therapy

Seyedeh Alia Moosavian1, Amirhossein Sahebkar2

  • 1Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Cancer Letters
|February 15, 2019
PubMed

Insights

Aptamer-functionalized liposomes enhance chemotherapy delivery to tumors, improving efficacy and reducing side effects. This targeted drug delivery approach shows promise for effective cancer treatment.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Chemotherapy aims to increase drug accumulation in tumors and overcome resistance.
  • Liposomes are effective nanocarriers for passive tumor targeting.
  • Aptamer-functionalized liposomes represent a novel strategy for active cancer cell targeting.

Purpose of the Study:

  • To review aptamer-functionalized liposome platforms for cancer therapy.
  • To discuss functionalization approaches and factors influencing antitumor efficiency.
  • To provide an overview of aptamer-targeted liposomes based on cancer cell molecular targets.

Main Methods:

  • Review of scientific literature on aptamer-liposome conjugates.
  • Analysis of in vitro and in vivo studies demonstrating enhanced tumor cell uptake.
  • Examination of different aptamer selection and liposome functionalization strategies.

Main Results:

  • Aptamer-targeted liposomes demonstrate significantly enhanced cellular uptake in cancer cells.
  • Functionalization approaches impact the stability and targeting efficiency of liposomes.
  • Specific molecular targets on cancer cells can be effectively utilized for aptamer-based targeting.

Conclusions:

  • Aptamer-functionalized liposomes offer a promising platform for targeted cancer therapy.
  • Optimizing functionalization and target selection is crucial for maximizing antitumor effects.
  • This approach holds potential for improving chemotherapy outcomes by enhancing tumor drug delivery and reducing systemic toxicity.
Keywords:
AptamerChemotherapyDrug deliveryLiposome

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