Aptamer-functionalized liposomes for targeted cancer therapy.

Area of Science:

• Oncology
• Nanotechnology
• Biomedical Engineering

Background:

• Chemotherapy aims to increase drug accumulation in tumors and overcome resistance.
• Liposomes are effective nanocarriers for passive tumor targeting.
• Aptamer-functionalized liposomes represent a novel strategy for active cancer cell targeting.

Purpose of the Study:

• To review aptamer-functionalized liposome platforms for cancer therapy.
• To discuss functionalization approaches and factors influencing antitumor efficiency.
• To provide an overview of aptamer-targeted liposomes based on cancer cell molecular targets.

Main Methods:

• Review of scientific literature on aptamer-liposome conjugates.
• Analysis of in vitro and in vivo studies demonstrating enhanced tumor cell uptake.
• Examination of different aptamer selection and liposome functionalization strategies.

Main Results:

• Aptamer-targeted liposomes demonstrate significantly enhanced cellular uptake in cancer cells.
• Functionalization approaches impact the stability and targeting efficiency of liposomes.
• Specific molecular targets on cancer cells can be effectively utilized for aptamer-based targeting.

Conclusions:

• Aptamer-functionalized liposomes offer a promising platform for targeted cancer therapy.
• Optimizing functionalization and target selection is crucial for maximizing antitumor effects.
• This approach holds potential for improving chemotherapy outcomes by enhancing tumor drug delivery and reducing systemic toxicity.