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Nutritional sensing and its utility in treating obesity
1a Section of Investigative Medicine, Faculty of Medicine, Imperial College London, 6th Floor, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Expert Review of Endocrinology & Metabolism
|February 16, 2019
Summary
Obesity is a global health challenge with limited effective treatments. Targeting nutrient sensing pathways in the gut and brain offers potential for new anti-obesity strategies, but requires further investigation.
Area of Science:
- Physiology
- Neuroscience
- Endocrinology
Background:
- Obesity is a significant global health issue with inadequate current medical interventions.
- Nutrient sensing by the gastrointestinal tract and brain detects fuel substrates like carbohydrates, proteins, and fats.
- Specialized neural and hormonal pathways regulate these critical chemosensory mechanisms.
Purpose of the Study:
- To explore the potential of targeting central and peripheral chemosensory pathways for appetite regulation.
- To identify novel therapeutic targets for developing anti-obesity agents.
Main Methods:
- Review of existing literature on nutrient sensing pathways.
- Analysis of neural and hormonal regulation of appetite.
- Assessment of potential therapeutic manipulations of chemosensory mechanisms.
Main Results:
- Nutrient sensing pathways in the GI tract and brain play a crucial role in appetite regulation.
- Neural and hormonal signaling facilitates the recognition and response to nutrients.
- Manipulation of these pathways presents a potential avenue for appetite control.
Conclusions:
- Targeting nutrient sensing pathways, both centrally and peripherally, may offer novel strategies for combating obesity.
- Further research is essential to validate the therapeutic utility of these approaches for developing effective anti-obesity treatments.
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