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Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.1K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.3K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

14.0K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

12.0K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
12.0K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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Updated: Jan 29, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

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Maternal undernutrition and endocrine development.

Jane E Harding1, José Gb Derraik2, Frank H Bloomfield3

  • 1a Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand. j.harding@auckland.ac.nz.

Expert Review of Endocrinology & Metabolism
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

Maternal undernutrition during pregnancy can alter fetal development, impacting offspring health long-term. These effects, influenced by timing and severity, may even affect future generations.

Keywords:
developmental origins of health and diseasefetal growthfetusglucose–insulin axishypothalamic–pituitary–adrenal axismaternal undernutrition

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Methods to Test Endocrine Disruption in Drosophila melanogaster
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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Maternal undernutrition poses significant global health challenges, affecting offspring health across the lifespan.
  • Nutritional insults during critical developmental windows can induce lasting physiological changes.
  • Understanding these effects is crucial for public health interventions.

Purpose of the Study:

  • To review the endocrine pathways disrupted by maternal undernutrition.
  • To elucidate the mechanisms linking maternal nutrition to long-term offspring health.
  • To highlight the intergenerational impact of nutritional deficits.

Main Methods:

  • Literature review focusing on endocrine disruptions.
  • Analysis of studies examining maternal nutritional insults and offspring outcomes.
  • Synthesis of evidence on timing, severity, and duration of undernutrition.

Main Results:

  • Maternal undernutrition induces physiological adaptations in the fetus.
  • Specific endocrine pathways are implicated in long-term health consequences.
  • Offspring gender and fetal number can modify outcomes.
  • Effects can persist across generations.

Conclusions:

  • Maternal undernutrition has profound and lasting effects on offspring health via endocrine disruption.
  • Interventions are needed to mitigate the mortality and morbidity associated with these effects.
  • Further research into ameliorative strategies is warranted.