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Related Experiment Video

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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Lung function trajectories in health and disease.

Alvar Agusti¹, Rosa Faner²

¹Respiratory Institute, Hospital Clinic, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Instituto de Salud Carlos III (CIBER), Madrid, Spain.

The Lancet. Respiratory Medicine

|February 16, 2019

Summary

Lung function follows three life stages: growth, plateau, and decline. Understanding diverse lung function trajectories and influencing factors is key to promoting respiratory health.

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Area of Science:

Pulmonology
Physiology
Life Course Epidemiology

Background:

Normal lung function progresses through distinct life phases: growth, plateau, and age-related decline.
Genetic and environmental factors significantly influence lung function trajectories across the lifespan.
Variations in lung function trajectories are linked to health and disease outcomes.

Purpose of the Study:

To review current evidence on lung function trajectories throughout life.
To identify key questions and challenges in understanding these trajectories.
To explore opportunities for promoting respiratory health.

Main Methods:

Literature review of studies on lung function development, ageing, and influencing factors.
Synthesis of evidence on diverse lung function trajectories.
Identification of research gaps and future directions.

Main Results:

Multiple distinct lung function trajectories exist beyond the typical three phases.
Factors influencing these trajectories include genetics, environment, and lifestyle.
Certain trajectories are associated with increased risk of respiratory diseases.

Conclusions:

Recognizing diverse lung function trajectories is crucial for personalized respiratory care.
Further research is needed to elucidate the mechanisms underlying altered trajectories.
Interventions targeting modifiable factors may improve long-term respiratory health outcomes.