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Microporous polysaccharide hemosphere efficacy and safety in primary total knee arthroplasty

Scott Gleason1, David Mehl1, William Payne1

  • 1Midwestern University/Franciscan St. James Health, 20201 South Crawford Ave, Olympia Fields, IL, 60461, USA.

Journal of Orthopaedics
|February 16, 2019
PubMed

Insights

Microporous polysaccharide hemospheres (MPH) did not improve safety or effectiveness in total knee arthroplasty (TKA). This study found MPH use led to greater blood loss without reducing complications, suggesting it may be unnecessary for TKA patients.

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science

Background:

  • Absorbable hemostats, including microporous polysaccharide hemospheres (MPH), are utilized in total knee arthroplasty (TKA) to control bleeding and minimize complications.
  • The efficacy and safety of MPH in TKA procedures require thorough investigation.

Purpose of the Study:

  • To evaluate the safety and effectiveness of using microporous polysaccharide hemospheres (MPH) in patients undergoing total knee arthroplasty (TKA).

Main Methods:

  • A retrospective review of patient records was conducted.
  • Data collected included blood loss, incidence of hematomas, and infections following TKA.
  • Statistical analysis was performed to compare outcomes between patients who received MPH and those who did not.

Main Results:

  • No significant differences were observed in demographics, superficial infection rates (P=0.933), or hematoma formation (P=0.393) between the groups.
  • A positive correlation was found between hematoma occurrence and superficial infection (P=0.009).
  • Patients treated with MPH experienced significantly greater blood loss (P=0.014) and demonstrated inferior bleeding control.

Conclusions:

  • Microporous polysaccharide hemospheres (MPH) did not demonstrate effectiveness in improving bleeding control or reducing complications in total knee arthroplasty (TKA).
  • The use of MPH in TKA was associated with increased blood loss and showed no benefit in preventing hematomas or infections.
  • The findings suggest that the routine application of MPH in TKA may not be necessary and could potentially be detrimental due to increased blood loss.
Keywords:
Arista®AHComplicationsHematomaHemostasisMicroporous polysaccharide hemospheresTotal knee arthroplasty

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