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Concentrated Insulins: A Review and Recommendations.

Jasmine D Gonzalvo1, Dhiren K Patel1, Jacqueline L Olin1

  • 1is a clinical pharmacy specialist at Eskenazi Health in Indianapolis and a clinical associate professor at Purdue University College of Pharmacy in Lafayette, both in Indiana. is a clinical pharmacy specialist at VA Boston Healthcare System and an associate professor of pharmacy practice at Massachusetts College of Pharmacy and Health Sciences in Boston. is a clinical pharmacy specialist at Novant Health Presbyterian Medical Center in Charlotte and a professor at Wingate University School of Pharmacy, both in North Carolina.

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Summary

Pen-delivered concentrated insulins help diabetes mellitus patients needing higher insulin doses. These concentrated forms use smaller volumes, potentially reducing the risk of medication dosing errors.

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Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus management often requires escalating insulin doses.
  • High insulin doses can present challenges in administration and accuracy.

Purpose of the Study:

  • To evaluate the benefits of pen-delivered concentrated insulins for patients with diabetes mellitus requiring higher insulin doses.

Main Methods:

  • Comparative analysis of insulin delivery methods.
  • Assessment of insulin volume and potential for dosing errors.

Main Results:

  • Pen-delivered concentrated insulins provide smaller administration volumes compared to traditional methods.
  • This reduction in volume may correlate with a decreased risk of dosing inaccuracies.

Conclusions:

  • Concentrated insulins delivered via pens are a viable option for managing high-dose insulin needs in diabetes.
  • This delivery method shows promise in enhancing patient safety by minimizing dosing errors.