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An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
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Variation in Mutant Prevention Concentrations.

Crystal Gianvecchio1, Natalie Ann Lozano1, Claire Henderson1

  • 1Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.

Frontiers in Microbiology
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

The mutant prevention concentration (MPC) for bacterial antibiotic resistance shows significant variation within a single strain-antibiotic combination, unlike the minimum inhibitory concentration (MIC). This high variability in MPC has important implications for understanding resistance evolution.

Keywords:
Staphylococcus epidermidisantibiotic resistancerepeatabilityreplicationselection

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Area of Science:

  • Evolutionary biology
  • Microbiology
  • Genetics

Background:

  • Understanding phenotypic trait variation is crucial for evolutionary biology.
  • Antibiotic resistance in bacteria is often characterized by minimum inhibitory concentration (MIC), which typically shows low strain-specific variation.
  • The mutant prevention concentration (MPC), representing the MIC of the most resistant sub-population, is less understood regarding its variability.

Purpose of the Study:

  • To investigate the variability of the mutant prevention concentration (MPC) within a single bacterial strain-antibiotic combination.
  • To determine how MPC distributions change with the evolution of antibiotic resistance.

Main Methods:

  • Used a Staphylococcus species and five distinct antibiotic classes (ciprofloxacin, doxycycline, gentamicin, nitrofurantoin, oxacillin).
  • Examined resistance frequencies across a wide range of antibiotic concentrations.
  • Measured the repeatability of the MPC, defined as the minimum antibiotic concentration preventing survival in a 10^10 bacterial population.

Main Results:

  • Observed substantial variation in MPC values for a given strain-antibiotic pair.
  • Found that MPC distributions were typically non-normal.
  • Demonstrated that evolved antibiotic resistance led to wider and sometimes multi-modal MPC distributions.

Conclusions:

  • Contrary to the MIC, the MPC exhibits high variability for specific bacterial strain-antibiotic combinations.
  • The variability of MPC is influenced by the evolution of antibiotic resistance.