3D Printing in Personalized Drug Delivery.

Area of Science:

• Pharmaceutical Sciences
• Biotechnology
• Materials Science

Background:

• Personalized medicine leverages patient genomics for improved drug design and reduced side effects.
• 3D printing offers a novel approach to creating patient-specific dosage forms.
• Combining multiple medications into a single dosage form is a key advantage.

Purpose of the Study:

• To review the application of 3D printing technology in personalized medicine.
• To discuss various 3D printing techniques and materials used in drug delivery.
• To explore the potential of 3D printing for treating complex diseases.

Main Methods:

• 3D printing utilizes digitally controlled layer-by-layer fabrication of Active Pharmaceutical Ingredients (APIs) and excipients.
• Techniques include inkjet printing and fused deposition modeling (FDM).
• Polymers such as polyvinyl alcohol, poly (lactic acid) (PLA), and poly (caprolactone) (PCL) are employed.

Main Results:

• 3D printing can produce diverse dosage forms like immediate release, pulsatile release, and transdermal systems.
• The technology facilitates the development of personalized medicines for life-threatening conditions.
• Single dosage forms incorporating multiple drugs can be designed for patients with complex regimens.

Conclusions:

• 3D printing is a promising technology for advancing personalized medicine.
• It offers tailored drug delivery systems with potential for reduced adverse effects, especially in cancer chemotherapy.
• Further exploration of 3D printing in drug delivery is warranted.