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Using Neuroimaging to Study the Effects of Pain, Analgesia, and Anesthesia on Brain Development

Jerri Chen1, Ghadah U Gadi1, Ashok Panigrahy2

  • 1Department of Anesthesiology, Columbia University Medical Center, New York, NY.

Journal of Neurosurgical Anesthesiology
|February 16, 2019
PubMed

Insights

Advanced neuroimaging techniques can detect specific brain changes in children due to pain and anesthesia. These findings help understand the effects of anesthetic medications on pediatric neurodevelopment.

Area of Science:

  • Pediatric neurodevelopmental research
  • Neuroscience
  • Anesthesiology

Background:

  • Neuroimaging is crucial for studying pain, analgesia, and anesthetic effects on children's brain development.
  • The 2016 FDA safety warning highlighted potential neurotoxicity of anesthetic/sedative drugs in pediatric patients.
  • The Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium focused on these concerns.

Purpose of the Study:

  • To discuss the utility of neuroimaging in assessing brain changes in children exposed to pain and anesthetics.
  • To evaluate advanced neuroimaging techniques for detecting structural, metabolic, and functional alterations.

Main Methods:

  • Utilized multimodal magnetic resonance imaging (MRI) techniques.
  • Focused on detecting changes related to pain and anesthetic agent exposure in pediatric subjects.

Main Results:

  • Advanced multimodal MRI effectively detects structural, metabolic, and functional brain changes.
  • Observed changes were specific to the type of pain and anesthetic agent used.

Conclusions:

  • Multimodal MRI is a valuable tool for assessing anesthetic and pain-related neurodevelopmental impacts in children.
  • Neuroimaging findings are specific to pain and anesthetic agents, aiding in targeted safety assessments.

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