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PPAR-γ: Its ligand and its regulation by microRNAs
Parvaneh Seiri1, Abbas Abi2, Mohammad Soukhtanloo1
1Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of Cellular Biochemistry
|February 17, 2019
Summary
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is crucial for metabolic health and implicated in diseases. MicroRNAs (miRNAs) are key regulators of PPAR-γ, offering insights into disease mechanisms.
Area of Science:
- Molecular Biology
- Cell Biology
- Endocrinology
Background:
- Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with subtypes PPARα, β/δ, and γ.
- PPAR-γ regulates energy balance, metabolism, insulin sensitivity, oxidative stress, and inflammation.
- PPAR-γ is implicated in obesity, diabetes, atherosclerosis, and cancer.
Purpose of the Study:
- To summarize the function and ligands of PPAR-γ.
- To highlight microRNAs (miRNAs) involved in PPAR-γ regulation.
- To understand the role of miRNA-mediated PPAR-γ regulation in diseases.
Main Methods:
- Literature review on PPAR-γ function, ligands, and miRNA interactions.
- Analysis of studies investigating miRNA regulation of PPAR-γ pathways.
- Synthesis of current knowledge on PPAR-γ and miRNA interplay.
Main Results:
- PPAR-γ is activated by metabolic derivatives and fatty acids.
- miRNAs are identified as significant regulators of PPAR-γ.
- Deregulation of miRNAs targeting PPAR-γ impacts disease initiation and progression.
Conclusions:
- Understanding miRNA regulation of PPAR-γ is vital for comprehending its role in health and disease.
- Targeting miRNA-PPAR-γ interactions may offer therapeutic strategies.
- Further research into specific miRNA-PPAR-γ networks is warranted.
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