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Updated: Jan 29, 2026

How to Build a Laser Speckle Contrast Imaging LSCI System to Monitor Blood Flow
Published on: November 11, 2010
[Development of Blood Flow and Oxygen Monitoring System for Mice Based on Laser Speckle and Spectrum]
Yuemei Zhao1, Yanbai Xue1, Yan Zhang1
1Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106.
Abstract:
In vivo simultaneous monitoring of blood flow and changes of concentration of oxyhemoglobin (ΔHbO2) in brain is a key important method for the research of cerebrovascular disease. In this study, a new monitoring system, combining laser speckle contrast imaging method and spectral analysis method, was proposed, which could be utilized to measure the cerebral blood flow and ΔHbO2 on mice during traumatic brain injury. The principle of the present system was studied and the hardware platform of the detection system was built. Then, user interface software and algorithms were implemented based on Labview and Matlab software. Finally, the performance of the present system was verified by the in vivo experiments.
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