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Bioavailability Enhancement: Drug Solubility Enhancement

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Related Experiment Video

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Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

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Enhancing Curcumin Oral Bioavailability Through Nanoformulations.

Vinod S Ipar¹, Anisha Dsouza², Padma V Devarajan³

¹Institute of Chemical Technology, Mumbai, India.

European Journal of Drug Metabolism and Pharmacokinetics

|February 17, 2019

Summary

This summary is machine-generated.

Curcumin shows therapeutic promise but faces bioavailability challenges. Nano-based delivery systems offer a promising strategy to enhance curcumin

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Area of Science:

Pharmacology and Drug Delivery
Natural Product Chemistry

Background:

Curcumin exhibits diverse therapeutic activities but suffers from poor aqueous solubility, low permeability, and P-glycoprotein (P-gp) efflux.
Active metabolites of curcumin also present therapeutic potential, necessitating strategies for their effective delivery.

Purpose of the Study:

To review and discuss strategies for the oral bioenhancement of curcumin, focusing on nano-based approaches.
To highlight the advantages of nanosystems in overcoming curcumin's pharmacokinetic limitations.

Main Methods:

Review of conventional bioenhancement techniques including cyclodextrin complexes, solid dispersions, and self-emulsifying drug delivery systems.
Detailed examination of various nano-based delivery systems for curcumin, such as nanosuspensions, lipid-based systems (liposomes, solid lipid nanoparticles), nanoemulsions, and polymeric nanoparticles.
Inclusion of miscellaneous nanosystems like inorganic nanoparticles, micelles, phytosomes, and dendrimers.

Main Results:

Nanosystems offer significant advantages for improving curcumin's bioavailability and therapeutic efficacy.
Various carrier-based nanosystems, including lipid-based formulations and polymeric nanoparticles, have been extensively explored for curcumin delivery.
Targeted oral delivery of curcumin using intact nanoparticles is a promising future direction.

Conclusions:

Nano-based approaches represent a powerful strategy to overcome the bioavailability challenges associated with curcumin.
The development of advanced nanosystems holds significant potential for harnessing curcumin's therapeutic benefits as a 'wonder nutraceutical'.
Targeted nanoparticle delivery systems could revolutionize the oral administration of curcumin for enhanced therapeutic outcomes.