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Updated: Aug 19, 2026

Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function
Ondrej Cerny1, David W Holden1
1MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ, UK.
Abstract:
Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. In this review, we discuss processes that are hijacked by SPI-2 T3SS effectors and how this affects DC biology and the activation of T cell responses.
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