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Is Hypoxia Related to External Cervical Resorption? A Case Report
Athina Maria Mavridou1, Petra Hilkens2, Ivo Lambrichts2
1Department of Oral Health Sciences, BIOMAT Research Cluster, KU Leuven and University Hospitals Leuven, Leuven, Belgium; Private Practice, Endo Rotterdam, Rotterdam, The Netherlands.
Journal of Endodontics
|February 18, 2019
Summary
Hypoxia, a state of low oxygen, is confirmed in external cervical resorption (ECR). This study reveals a hypoxia gradient within ECR lesions, suggesting its role in tooth resorption and pulp stone formation.
Area of Science:
- Endodontics
- Oral Pathology
- Cellular Biology
Background:
- External cervical resorption (ECR) is a common dental condition with an unclear etiology.
- Recent research suggests a potential link between hypoxia and the development of ECR.
Observation:
- This case study utilized advanced imaging (CBCT, nanofocus CT) and immunohistology to investigate hypoxia in ECR.
- Hypoxia-inducible factor 1-alpha (HIF-1α) positive cells were quantified in different regions of the ECR lesion and pulp.
Findings:
- A higher concentration of HIF-1α positive cells was observed in the apical ECR area compared to the coronal area.
- Pulp stones, indicative of a hypoxic pulp environment, were found in areas with elevated hypoxia.
- Histological analysis revealed a layered remodeling pattern in ECR, potentially influenced by hypoxia.
Implications:
- This study confirms the presence of hypoxia in ECR and demonstrates a hypoxia gradient within the lesion.
- The findings suggest that hypoxia plays a significant role in the pathogenesis of ECR and associated pulp changes.
- Understanding the role of hypoxia may lead to novel therapeutic strategies for managing ECR.
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