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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Updated: Jan 29, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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Innate lymphoid cells in intestinal cancer development.

Imke Atreya1, Markus Kindermann1, Stefan Wirtz1

  • 1Department of Medicine 1, Friedrich-Alexander-University, Erlangen, Germany.

Seminars in Immunology
|February 18, 2019
PubMed
Summary
This summary is machine-generated.

Innate lymphoid cells (ILCs) are key immune cells in the gut. This review explores their dual role in intestinal homeostasis and colorectal cancer development, highlighting their therapeutic potential.

Keywords:
Colorectal cancerGut immune systemILC1ILC2ILC3Innate lymphoid cells

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Area of Science:

  • Immunology
  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
  • Immune cell functions within the colorectal tumor microenvironment are complex and heterogeneous.
  • Dysregulated immune cell composition and activation are critical in CRC progression.

Purpose of the Study:

  • To review the multifaceted roles of innate lymphoid cells (ILCs) in maintaining intestinal homeostasis.
  • To discuss emerging evidence on the involvement of ILCs in intestinal cancer development and growth.
  • To highlight ILCs as potential targets for novel cancer therapies.

Main Methods:

  • Literature review of recent studies on ILCs in gastrointestinal health and disease.
  • Analysis of ILC subset functions in the context of intestinal homeostasis.
  • Examination of ILC involvement in the pathogenesis of colorectal cancer.

Main Results:

  • ILCs play significant roles in regulating gastrointestinal homeostasis.
  • Evidence suggests ILCs are implicated in the development and progression of intestinal cancers.
  • ILCs possess potent immunomodulatory properties relevant to cancer therapy.

Conclusions:

  • Innate lymphoid cells are crucial for intestinal health and disease.
  • Understanding ILC functions in colorectal cancer is vital for therapeutic strategies.
  • ILCs represent promising targets for future colorectal cancer treatments.