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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
Published on: March 23, 2022
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Innate lymphoid cells in intestinal cancer development
Imke Atreya1, Markus Kindermann1, Stefan Wirtz1
1Department of Medicine 1, Friedrich-Alexander-University, Erlangen, Germany.
Seminars in Immunology
|February 18, 2019
Summary
Innate lymphoid cells (ILCs) are key immune cells in the gut. This review explores their dual role in intestinal homeostasis and colorectal cancer development, highlighting their therapeutic potential.
Area of Science:
- Immunology
- Oncology
- Gastroenterology
Background:
- Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
- Immune cell functions within the colorectal tumor microenvironment are complex and heterogeneous.
- Dysregulated immune cell composition and activation are critical in CRC progression.
Purpose of the Study:
- To review the multifaceted roles of innate lymphoid cells (ILCs) in maintaining intestinal homeostasis.
- To discuss emerging evidence on the involvement of ILCs in intestinal cancer development and growth.
- To highlight ILCs as potential targets for novel cancer therapies.
Main Methods:
- Literature review of recent studies on ILCs in gastrointestinal health and disease.
- Analysis of ILC subset functions in the context of intestinal homeostasis.
- Examination of ILC involvement in the pathogenesis of colorectal cancer.
Main Results:
- ILCs play significant roles in regulating gastrointestinal homeostasis.
- Evidence suggests ILCs are implicated in the development and progression of intestinal cancers.
- ILCs possess potent immunomodulatory properties relevant to cancer therapy.
Conclusions:
- Innate lymphoid cells are crucial for intestinal health and disease.
- Understanding ILC functions in colorectal cancer is vital for therapeutic strategies.
- ILCs represent promising targets for future colorectal cancer treatments.
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