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Therapeutics strategies against cancer stem cell in breast cancer

Faezeh Ghasemi1, Parisa Zia Sarabi2, Seyyed Shamsadin Athari3

  • 1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

The International Journal of Biochemistry & Cell Biology
|February 18, 2019
PubMed

Insights

Breast cancer stem cells (CSCs) are crucial targets for new therapies. Targeting CSCs offers promising strategies to overcome conventional treatment limitations and improve breast cancer outcomes.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunotherapy

Background:

  • Breast cancer is a leading cause of cancer-related deaths globally.
  • Conventional therapies face limitations, necessitating novel therapeutic targets.
  • Cancer stem cells (CSCs) play a significant role in tumor growth and resistance.

Purpose of the Study:

  • To review therapeutic strategies targeting breast cancer stem cells (CSCs).
  • To highlight the potential of CSC-targeted therapies in overcoming treatment resistance.
  • To explore CSCs as targets for novel breast cancer immunotherapy.

Main Methods:

  • Review of current literature on CSCs in breast cancer.
  • Analysis of therapeutic strategies targeting CSC surface markers and signaling pathways.
  • Examination of approaches like miRNA therapy, apoptosis induction, and differentiation therapy.

Main Results:

  • CSCs are implicated in tumor recurrence and metastasis.
  • Targeting specific CSC markers and pathways (e.g., Notch, Wnt) shows therapeutic potential.
  • Various strategies, including natural compounds and immunotherapy, are being explored for CSC targeting.

Conclusions:

  • Cancer stem cells represent a critical target for effective breast cancer treatment.
  • Targeting CSCs offers a promising avenue for developing novel therapeutic and immunotherapeutic approaches.
  • Further research into CSC manipulation is essential for advancing breast cancer therapy.
Keywords:
BMP and TGF-β signaling pathwaysBreast cancerCancer stem cellHedgehogNF-kBNotchPI3K/AktWnt/b-catenin

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