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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Related Experiment Video

Updated: Jan 29, 2026

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
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[Recent studies on the signaling pathways implicated myopia].

Z Liu1, W S Chen, Z G Liu

  • 1Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|February 18, 2019
PubMed
Summary
This summary is machine-generated.

Myopia, a significant health concern in China, is influenced by genetics and environment. This review explores key signaling pathways involved in myopia development and axial elongation.

Keywords:
Axial length, eyeMyopiaSignal transduction

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Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Myopia prevalence is rising in China, posing a major public health challenge.
  • Myopia results from genetic and environmental factors, involving complex biological processes.
  • Abnormal visual stimuli can trigger retinal changes leading to scleral remodeling and eye elongation.

Purpose of the Study:

  • To review critical signaling pathways implicated in myopia development.
  • To understand the molecular mechanisms underlying axial elongation in myopia.

Main Methods:

  • Literature review of studies on myopia and signaling pathways.
  • Analysis of research linking visual stimulation to retinal and scleral changes.
  • Synthesis of information on key molecular pathways involved in eye growth.

Main Results:

  • Signaling pathways are crucial in regulating retinal neurotransmitters and growth factors.
  • These pathways mediate scleral remodeling and axial elongation.
  • Specific pathways are identified as important in myopia pathogenesis.

Conclusions:

  • Understanding these signaling pathways is key to addressing myopia.
  • Further research into these pathways may reveal therapeutic targets.
  • Targeting molecular mechanisms could help control myopia progression.