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[Hemolytic disorders and venous thrombosis: An update]

M Lecouffe-Desprets1, J Graveleau1, M Artifoni1

  • 1Service de médecine interne, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.

La Revue De Medecine Interne
|February 19, 2019
PubMed

Many factors can contribute to the risk of venous thrombosis observed in hemolytic diseases. Some mechanisms are related to hemolysis by itself, while others seem more specific to each disease. Despite recent advances in the quantification of this risk and in understanding its physiopathology, the association of hemolysis with venous thrombosis is often unknown. The purpose of this general review is to clarify the main pro-thrombotic mechanisms during hemolysis and to synthesize the clinical data currently available. We will focus on the main types of hemolytic pathologies encountered in current practice, namely paroxysmal nocturnal hemoglobinuria, hemoglobinopathies, auto-immune hemolytic anemia and thrombotic microangiopathies.

Keywords:
Anémie hémolytique auto-immuneAuto-immune hemolytic anemiaHemoglobinopathiesHemolysisHémoglobinopathiesHémoglobinurie paroxystique nocturneHémolyseParoxysmal nocturnal hemoglobinuriaThrombose veineuseVenous thrombosis

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