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Tachykinin upregulation in atopic dermatitis
Louise Lönndahl1,2, Aram Rasul1,3, Sol-Britt Lonne-Rahm1
1a Department of Medicine Solna, Dermatology and Venereology Unit , Karolinska Institutet , Stockholm , Sweden.
Immunopharmacology and Immunotoxicology
|February 19, 2019
Summary
Stress and inflammation in atopic dermatitis (AD) involve tachykinins. This study found increased tachykinin markers in AD skin, linking them to depression and skin inflammation.
Area of Science:
- Dermatology
- Neuroscience
- Immunology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition exacerbated by psychological stress.
- Tachykinins are implicated in both inflammatory signaling and stress-related responses.
Purpose of the Study:
- To quantify tachykinin marker expression in the skin of AD patients.
- To explore correlations between tachykinin levels and clinical/psychodemographic factors in AD.
Main Methods:
- Immunohistochemical analysis of skin biopsies from 28 adult AD patients.
- Assessment of clinical and psychodemographic parameters.
Main Results:
- Elevated substance P and neurokinin A (NKA) positive nerve fibers in lesional AD skin.
- Increased NKA-positive dermal cells and correlation between depression scores and NK-1 receptor positive cells in lesional and non-lesional skin.
Conclusions:
- The tachykinergic system is upregulated in the inflamed skin of atopic dermatitis patients.
- Tachykinins may play a role in the interplay between skin inflammation and psychological factors in AD.
