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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Construction of lumped-parameter cardiovascular models using the CellML language
Yubing Shi1, Patricia Lawford1, D Rodney Hose1
1a Medical Physics Unit, Department of Cardiovascular Science, Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.
Abstract:
Lumped-parameter models are widely used by cardiovascular researchers in the analysis of the circulatory dynamics. However, portability and model exchange have always been a problem, with different researchers implement the model differently. To improve the situation, in this study, a group of lumped-parameter cardiovascular system models with different levels of complexity have been implemented using the CellML mark-up language. The models have been curated and made publicly available in the CellML model repository, and the purpose of this paper is to provide further technical details to support the usage of these models by the research community. The developed models are validated and tested under the OpenCell environment as part of the curation process. Simulation results agree well with typical published data on cardiovascular system response.
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