[Experimental direction and development of synthetic vascular grafts]

In this paper a review of the present achievements as far as the usage of vascular prostheses is concerned was made. The attention was paid to the regeneration of endothelium cells and cells of smooth muscles in the morphogenesis of the neointima. The actual views concerning the causes of failures of nowadays applied graft, in particular those used to average and small arteries were presented. The interaction of the materials and vascular grafts of plastics with blood platelets as well as with plasmatic components of the clotting system and fibrinolysis was described. The changing hemostatic properties of synthetic vascular grafts, and particularly the thrombogenicity of their internal surface was characterized. The factors which can have an influence upon the non-thrombogenicity of the surface of the future, better vascular prosthesis, and some directions of the experiments that can influence the production of better, then now available vascular prostheses in future.