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Evaluation of the cardiovascular risk in patients with biliary stones: a descriptive cross-sectional study

Shermin Seddighi1, Mohammad Esmaiel Ghidari1, Amir Sadeghi2

  • 1Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gastroenterology and Hepatology From Bed to Bench
|February 19, 2019
PubMed

Insights

This study found that individuals with gallstones do not have a higher risk of cardiovascular disease compared to the general population. Key liver enzymes were elevated in gallstone patients, but cardiovascular risk scores were not significantly different.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Public Health

Background:

  • Gallstones are a prevalent biliary system disorder with increasing incidence.
  • Cardiovascular disease remains the leading cause of global mortality.
  • Shared risk factors may link gallstones and cardiovascular disease.

Purpose of the Study:

  • To evaluate the association between gallstones and the risk of developing cardiovascular disease.
  • To compare cardiovascular disease risk in patients with gallstones versus a healthy control group.

Main Methods:

  • A descriptive cross-sectional study involving 105 patients with gallstones and 105 healthy controls.
  • Data collection included demographics, medical history, clinical examination, blood tests, echocardiography, and ultrasonography.
  • Cardiovascular risk was assessed using Framingham and ASCVD risk scores.

Main Results:

  • No significant difference in major cardiovascular risk factors between groups.
  • Patients with gallstones showed significantly higher levels of ALT, AST, and ALP enzymes (P<0.05).
  • Average Framingham risk scores were similar; ASCVD scores were statistically lower in the gallstone group.

Conclusions:

  • The study concludes that gallstones are not associated with an increased risk of cardiovascular disease in the studied population.
  • Elevated liver enzymes in gallstone patients warrant further investigation regarding their clinical significance.
Abstract

Keywords:
Cardiovascular diseaseGallstonesRisk factors

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