Related Experiment Video
Updated: Jan 29, 2026

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Published on: January 6, 2023
Network analysis of grade II into grade III transition in rectum cancer patients
Mohammad Rostami-Nejad1, Vahid Mansouri2, Reza Mahmoud Robati3
1Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aim:
Finding important differential genes between grade II and grade III of rectum cancer was the aim of this study.
Background:
Colorectal (CRC) cancers (CRC) are known as the third diagnosed cancer and the second leading to death cancers. Life style is an important risk factor of CRCs. Diagnosis of rectum cancer estimated as 44% of colon cancer.
Methods:
Differentially expressed genes (DEGS) related to grade II into grade II in 6 patients are retrieved from gene expression omnibus (GEO) and investigated by protein-protein interaction (PPI) network analysis. Central nodes of the network are identified and enriched to determine biochemical pathways. Action map is illustrated for the central genes.
Results:
Among 15 central genes including AKT1, PRDM10, GAPDH, TP53, SRC, EGFR, ALB, INS, CTNNB1, EGF, IL6, RHOA, DECR1, ACACA, GMPS role of AKT1 is highlighted due to prominent role in the integrity of the network and participation in the most determined pathways. However, significant regulatory effect of INS, AKT1, EGF, EGFR, and CTNNB1 is tinted in action map.
Conclusion:
It seems that AKT1, EGFR, and TP3 are suitable drug targets to prevent rectum cancer progression.
Related Concept Videos
Sieve Analysis and Grading Curves
Graded Potential
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Types of Aggregate Grading
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Phase Transitions
Phase Transitions: Vaporization and Condensation

