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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Protein-protein Interfaces02:04

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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The Thoracic Cage: Sternum01:17

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The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
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The Thoracic Cage: Ribs01:20

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Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
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Peptide Identification Using Tandem Mass Spectrometry01:33

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Activatable cell-biomaterial interfacing with photo-caged peptides.

Yiyang Lin1, Manuel M Mazo1, Stacey C Skaalure1

  • 1Department of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK .

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Researchers developed a new light-activated peptide system to control cellular uptake of various materials and cell adhesion. This innovation enables precise, remote regulation of drug delivery and biointerfaces for smart biomaterials.

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Area of Science:

  • Biomaterials Science
  • Cellular Biology
  • Nanotechnology

Background:

  • Tailoring cell-material interactions is crucial for advanced drug delivery and biointerfaces.
  • Existing methods often lack precise spatial and temporal control.

Purpose of the Study:

  • To create photo-activatable cell-material interfacing systems.
  • To enable light-triggered cellular uptake and cell adhesion.
  • To demonstrate remote control over cargo delivery into cells.

Main Methods:

  • Design of a novel photo-caged peptide that transitions from antifouling to cell-penetrating upon light exposure.
  • Conjugation of the peptide to various cargoes (nanoparticles, proteins, etc.).
  • Demonstration of light-controlled cellular uptake, drug delivery, and cell adhesion using optical methods.

Main Results:

  • Photo-activated uptake of diverse cargoes including nanoparticles, quantum dots, and liposomes.
  • Remote regulation of camptothecin-loaded nanoparticles into cancer cells.
  • Light-controlled cell adhesion and 3D spatiotemporal control of nanoparticle uptake via two-photon excitation.

Conclusions:

  • The developed photo-activatable peptide system offers precise control over cell-material interactions.
  • This approach facilitates the creation of novel stimuli-responsive delivery systems and intelligent biomaterials.
  • The technology holds promise for advanced therapeutic applications and biointerface engineering.