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Updated: Jan 29, 2026

Isolating Primary Melanocyte-like Cells from the Mouse Heart
Published on: September 29, 2014
Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation
Lucinda Calheiros Guimarães1, Priscila Leandro Garcia1, João Badaró Castro1
1Federal University of Triângulo Mineiro (UFTM), Special Pathology Discipline. Uberaba, MG, Brazil.
Abstract:
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Two initial biopsies were inconclusive. Histopathological examination of the uterus revealed large cell neuroendocrine carcinoma associated with endometrioid carcinoma and foci of melanocytic differentiation, pT3a (FIGO IIIA). There were metastases in the rectum serosa and lungs. After 8 months of diagnosis and surgical treatment, the patient is on chemotherapy and radiotherapy. We highlight the morphological characteristics and criteria that allow the definitive anatomopathological diagnosis, including immunohistochemical markers used to identify the cell types present in this unprecedented association.
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