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Related Experiment Videos

Is Alzheimer's Disease Risk Modifiable?

Alberto Serrano-Pozo1,2, John H Growdon1,2

  • 1Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Journal of Alzheimer'S Disease : JAD
|February 19, 2019
PubMed
Summary

Mixed dementia, including Alzheimer's disease (AD) and cerebrovascular ischemic disease (CVID), is common in the elderly. Modifiable risk factors and healthy lifestyles may prevent a significant portion of dementia cases.

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Area of Science:

  • Neurology
  • Epidemiology
  • Geriatrics

Background:

  • Mixed dementia, particularly Alzheimer's disease (AD) and cerebrovascular ischemic disease (CVID), is more prevalent than pure AD in the elderly.
  • Mid-life vascular risk factors are linked to increased risk of late-onset dementia, including AD.
  • Healthy lifestyle choices like physical activity and diet show protective effects against AD.

Purpose of the Study:

  • To review evidence on modifiable risk factors for Alzheimer's disease (AD).
  • To analyze potential therapeutic and preventative interventions for AD.
  • To explore the impact of lifestyle and vascular health on dementia risk.

Main Methods:

  • Review of epidemiological studies on dementia risk factors.
  • Analysis of preclinical research on AD pathogenesis.
Keywords:
Alcohol drinkingAlzheimer’s diseasedementiadiabetes mellitusdieteducationexercisehyperlipidemiahypertensionsmoking

Related Experiment Videos

  • Examination of data from interventional studies for prevention and treatment.

    • Main Results:

    • Epidemiological data suggest a potential decrease in dementia incidence and prevalence in Western countries.
    • A substantial proportion of AD cases may be preventable through lifestyle modifications.
    • Strong association between mid-life vascular health and late-onset dementia risk.

    Conclusions:

    • Modifiable risk factors present opportunities for AD prevention.
    • Lifestyle interventions, including diet and exercise, are crucial for mitigating dementia risk.
    • Further research is needed to confirm trends and optimize preventative strategies.