Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Protein Networks02:26

Protein Networks

2.8K
2.8K
Surveys02:16

Surveys

16.8K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
16.8K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

14.5K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
14.5K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

4.5K
4.5K
Introduction to Surveying, Plane Surveying and Geodetic Surveys01:27

Introduction to Surveying, Plane Surveying and Geodetic Surveys

1.0K
Surveying is the art and science of mapping the earth's surface. It involves measuring distances, angles in horizontal or vertical directions, and levels to understand the shape and size of land features. Surveying techniques are essential for various tasks, such as identifying the levels of a land area with reference to a specific point, and mapping undulations and water bodies.There are two main types of surveying: plane surveys and geodetic surveys. Plane surveys assume the earth is flat,...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cytosolic class I small heat shock protein, RcHSP17.8, of Rosa chinensis confers resistance to a variety of stresses to Escherichia coli, yeast and Arabidopsis thaliana.

Plant, cell & environment·2009
Same author

Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.

Neurochemistry international·2009
Same author

[Clinical features of interstitial pneumonitis due to interferon alpha therapy for chronic hepatitis C].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2009
Same author

Anti-hypoxic activity of the ethanol extract from Portulaca oleracea in mice.

Journal of ethnopharmacology·2009
Same author

[Effects of artemether and dihydroarteannuin on mouse model of scleroderma].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2009
Same author

Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats.

European journal of pharmacology·2009
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.8K

Network-based methods for predicting essential genes or proteins: a survey.

Xingyi Li1, Wenkai Li1, Min Zeng1

  • 1School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.

Briefings in Bioinformatics
|February 19, 2019
PubMed
Summary
This summary is machine-generated.

Predicting essential genes, critical for survival, is vital for disease research and drug development. Network-based computational methods offer an effective alternative to complex laboratory techniques.

Keywords:
biological informationdynamic featuresessential genes/proteinsnetwork-based methodstopological characteristics

More Related Videos

Methods for Image-based Surveys of Benthic Macroinvertebrates and Their Habitat Exemplified by the Drop Camera Survey for the Atlantic Sea Scallop
07:43

Methods for Image-based Surveys of Benthic Macroinvertebrates and Their Habitat Exemplified by the Drop Camera Survey for the Atlantic Sea Scallop

Published on: July 2, 2018

10.1K
Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.4K

Related Experiment Videos

Last Updated: Jan 29, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.8K
Methods for Image-based Surveys of Benthic Macroinvertebrates and Their Habitat Exemplified by the Drop Camera Survey for the Atlantic Sea Scallop
07:43

Methods for Image-based Surveys of Benthic Macroinvertebrates and Their Habitat Exemplified by the Drop Camera Survey for the Atlantic Sea Scallop

Published on: July 2, 2018

10.1K
Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.4K

Area of Science:

  • Genomics
  • Systems Biology
  • Bioinformatics

Background:

  • Essential genes are critical for organism or cell survival.
  • Predicting essential genes aids in understanding complex diseases, minimal genomes, and drug target discovery.
  • Laboratory methods for identification are often complex, costly, and time-consuming.

Purpose of the Study:

  • To survey advanced network-based computational methods for predicting essential genes and proteins.
  • To highlight the effectiveness of network analysis in essential gene identification.
  • To discuss future research challenges and directions in the field.

Main Methods:

  • Analysis of topological characteristics in protein-protein interaction networks (PINs).
  • Integration of diverse biological information.
  • Consideration of dynamic features within PINs.
  • Network-based computational approaches.

Main Results:

  • Network-based methods are effective for identifying essential genes/proteins.
  • Topological analysis, biological information integration, and dynamic feature consideration enhance prediction accuracy.
  • Computational approaches provide a valuable alternative to experimental methods.

Conclusions:

  • Network-based prediction is a powerful strategy for identifying essential genes.
  • Further research is needed to address existing challenges and explore new directions.
  • This field holds significant promise for advancing biological and medical research.