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Published on: April 18, 2019
Sacubitril/Valsartan (Entresto®)-Induced Hyponatremia
Ilana Fuzaylova1, Chester Lam1, Om Talreja1
1College of Pharmacy and Health Sciences, 4131St. John's University, Jamaica, NY, USA.
Abstract:
Sacubitril/valsartan (Entresto®) is the first commercially available angiotensin receptor neprilysin inhibitor (ARNI) approved for use in heart failure patients with a reduced ejection fraction. It is a combination drug that contains sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Our report outlines a case of probable ARNI-induced hyponatremia occurring in an elderly woman with heart failure with a reduced ejection fraction. According to Naranjo Adverse Drug Reaction Assessment, score indicated a likely association between patient's hyponatremia and her use of sacubitril/valsartan.
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