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Updated: Jan 29, 2026
![Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58491.jpg&w=3840&q=50)
Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
Published on: August 8, 2019
Optimized Production and Biological Evaluation of 68Ga-PDTMP as a New Agent for PET Bone Scanning
Neda Tadayon1, Hassan Yousefnia2, Ali Ramazani1
1Department of Chemistry, University of Zanjan, Zanjan, Iran.
Introduction:
In this study, 68Ga-PDTMP was introduced as a novel agent for PET bone scanning.
Methods:
68Ga-PDTMP was prepared with radiochemical purity of higher than 98% at the optimized conditions.
Results:
Stability tests showed no decrease in radiochemical purity, even after 120 min. The capacity binding of 76.3% ± 0.7% after 10 min incubation for 68Ga-PDTMP was observed.
Conclusion:
Biological studies in normal mice demonstrated that most of the remained activity is transmitted from blood into bones. The results show that 68Ga-PDTMP can be considered as a potential radiolabelled complex for PET bone scanning.
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