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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Cost-effectiveness of preimplantation genetic testing for aneuploidies

Edgardo Somigliana¹, Andrea Busnelli², Alessio Paffoni³

¹Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Obstetrics-Gynecology Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Fertility and Sterility

|February 20, 2019

Abstract

Objective:

To evaluate the economical benefit of preimplantation genetic testing of aneuploidies (PGT-A) when applied in an extended culture and stringent elective single ET framework.

Design:

Theoretical cost-effectiveness study.

Setting:

Not applicable.

Patients/Animal(S):

None.

Intervention(S):

Comparison of the cost-effectiveness between two IVF treatment strategies: serial transfer of all available blastocysts without genetic testing (first fresh transfer and subsequent frozen-thawed transfer); and systematic use of genetic testing (trophectoderm biopsy, freeze-all, and frozen-thawed transfers of euploid blastocysts). The costs considered for this analysis are based on regional public health system provider.

Main Outcome Measure(S):

Costs per live birth.

Result(S):

Cost-effectiveness profile of PGT-A improves with female age and number of available blastocysts. Sensitivity analyses varying the costs of ET, the costs of genetic analyses, the magnitude of the detrimental impact of PGT-A on live birth rate, and the crude live birth rates change to some extent the thresholds for effectiveness but generally confirm the notion that PGT-A can be economically advantageous in some specific subgroups.

Conclusion(S):

PGT-A can be cost-effective in specific clinical settings and population groups. Economic considerations deserve attention in the debate regarding the clinical utility of PGT-A.

Keywords:

Preimplantation genetic testing blastocyst effectiveness elective single embryo transfer

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