Related Experiment Video
Updated: Jan 29, 2026
05:23
Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
4.4K
[Real-world migraine burden: clinical and economic aspects]
M V Naprienko1, L V Smekalkina2, M I Safonov2
1Alexander Vein Headache Clinic, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|February 20, 2019
Summary
Botulinum toxin type A (BTA) is the most effective treatment for chronic migraine (CM), significantly reducing headache frequency and improving quality of life. BTA offers the lowest cost per headache-free day despite higher initial expenses.
Area of Science:
- Neurology
- Pain Management
- Pharmacology
Background:
- Chronic migraine (CM) presents a significant burden on patients and healthcare systems.
- Evaluating different CM preventive treatments is crucial for optimizing patient care and resource allocation.
Purpose of the Study:
- To compare the clinical outcomes and financial implications of various CM preventive treatments in a real-world setting.
- To provide data for informed decision-making by clinicians and patients regarding CM management.
Main Methods:
- A comparative study involving 66 CM patients divided into three groups: oral topiramate, acupuncture, and botulinum toxin type A (BTA).
- Treatments were administered over three months, with efficacy assessed via clinical examination, HIT-6, and patient satisfaction questionnaires.
- Financial burden was evaluated by comparing direct costs and the cost per headache-free day.
Main Results:
- BTA demonstrated superior efficacy, leading to faster and more significant reductions in headache frequency compared to topiramate and acupuncture.
- BTA treatment resulted in quicker improvements in quality of life and better patient tolerability.
- Despite higher upfront costs, BTA yielded the lowest predicted cost per headache-free day.
Conclusions:
- Botulinum toxin type A (BTA) is a highly effective and cost-efficient strategy for chronic migraine prevention.
- The findings support BTA as an optimal treatment choice for managing chronic migraine, considering both clinical efficacy and economic factors.
![Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59557.jpg&w=3840&q=50)
Related Concept Videos
01:30Quantitative Aspects of Drug-Receptor Interaction
1.8K
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
1.8K
01:27Real Number System
963
The real number system includes all numbers used for counting, measuring, and comparing quantities. Natural numbers are the basic counting numbers: 1, 2, 3, and so on. Integers expand this set by including zero and negative whole numbers: ..., –3, –2, –1, 0, 1, 2, .... Rational numbers are those that can be expressed as the ratio of two integers m/n, where n≠0. This includes fractions like 1/2, integers such as 46, and decimals that terminate, such as 0.17, or...
963
01:27Nursing Clinical Information System
1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
01:16Clinical Trials
10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.4K
01:27Real Number Operations
305
The concept of real numbers includes all the values that can be represented on a continuous number line. The system began with basic counting values used for enumeration. It later expanded to include values that represent the absence of quantity and opposites of the counting values. When situations required expressing parts of a whole or dividing quantities evenly, values capable of representing such proportions were developed. When written using decimal notation, these values can end or repeat...
305
01:11Clinical Trials: Overview
4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K