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Related Concept Videos

Signal Transduction: Overview01:26

Signal Transduction: Overview

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Related Experiment Video

Updated: Jan 29, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

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Signal Transduction Pathways in Ageing.

Cathy Slack1, Jennifer Tullet2

  • 1School of Life and Health Sciences, Aston University, Birmingham, UK. c.slack@aston.ac.uk.

Sub-Cellular Biochemistry
|February 20, 2019
PubMed
Summary
This summary is machine-generated.

Ageing is controlled by conserved cellular pathways. Understanding these pathways and molecules helps develop therapies for age-related decline and diseases.

Keywords:
AMPKAgeingInsulin signallingRas/MAPKmTOR

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Area of Science:

  • Gerontology and molecular biology.
  • Cellular and molecular mechanisms of ageing.

Background:

  • Ageing is a complex process associated with functional decline.
  • Numerous molecules and cellular pathways regulate ageing.
  • Understanding these pathways is crucial for addressing age-related diseases.

Purpose of the Study:

  • To describe evolutionary conserved cellular signalling pathways governing ageing.
  • To discuss how identifying these pathways and molecules aids therapeutic strategy design.

Main Methods:

  • Review and synthesis of existing research on ageing pathways.
  • Analysis of molecular mechanisms within conserved signalling pathways.

Main Results:

  • Identification of key evolutionary conserved cellular signalling pathways regulating organismal ageing.
  • Demonstration of how molecular insights inform therapeutic interventions.
  • Highlighting the link between fundamental ageing research and clinical applications.

Conclusions:

  • Conserved cellular pathways are central to ageing.
  • Targeting these pathways and their molecules offers therapeutic potential.
  • Research in ageing mechanisms facilitates the development of strategies against age-related diseases.