Related Experiment Video
Updated: Jan 29, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
21.8K
Radionuclide-Activated Nanomaterials and Their Biomedical Applications
Carolina A Ferreira1, Dalong Ni1, Zachary T Rosenkrans1
1Departments of Radiology, Biomedical Engineering, and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA.
Angewandte Chemie (International Ed. in English)
|February 20, 2019
Summary
Radio-nanomedicine uses radiolabeled nanoparticles in nuclear medicine. Nanomaterials combined with Cerenkov radiation are revolutionizing diagnostics and therapeutics by enabling activatable applications.
Area of Science:
- Nuclear Medicine
- Nanotechnology
- Biomedical Imaging
Background:
- Radio-nanomedicine, utilizing radiolabeled nanoparticles, has gained significant traction.
- Cerenkov radiation and Cerenkov luminescence imaging have transformed nanomaterial roles.
- Nanomaterials are evolving from passive carriers to active agents in nuclear medicine.
Purpose of the Study:
- To comprehensively review nanomaterials interacting with Cerenkov radiation and radionuclide scintillation.
- To explore the biological applications of these advanced nanomaterials.
- To highlight the revolution in diagnostic and therapeutic nuclear medicine.
Main Methods:
- Literature review of nanomaterials used in conjunction with Cerenkov radiation.
- Analysis of nanomaterial interactions with gamma and beta scintillation from radionuclides.
- Compilation of current biological applications in radio-nanomedicine.
Main Results:
- Diverse nanomaterials have been identified for Cerenkov radiation interaction.
- Nanomaterials enhance both diagnostic imaging and therapeutic capabilities.
- Significant advancements in activatable radio-nanomedicine have been achieved.
Conclusions:
- The integration of nanomaterials with Cerenkov radiation offers novel diagnostic and therapeutic strategies.
- Radio-nanomedicine is a rapidly advancing field with broad biological applications.
- Future research will likely focus on further optimizing activatable nanomaterial systems.
Related Concept Videos
02:48Radioactive Decay and Radiometric Dating
37.1K
Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. The number of disintegrations per unit time is called the activity (A), which is directly proportional to the number of nuclei in the sample. The decay constant (λ) is an average probability of decay per nucleus in unit time.
37.1K
02:04Co-activators and Co-repressors
8.6K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.6K
01:14Photoluminescence: Applications
1.1K
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
1.1K
01:17Radiation: Applications
1.8K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.8K
01:28Applications of Logarithms
239
Logarithmic functions are powerful tools for simplifying the mathematical representation of phenomena involving exponential changes. Their ability to convert multiplicative relationships into additive ones is especially valuable in various scientific and engineering contexts. One notable application of logarithms is measuring sound intensity, specifically through the decibel (dB) scale used in acoustics.Sound intensity levels vary over an extensive range, from the faintest audible whisper to...
239
02:26tRNA Activation
22.9K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
22.9K