Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Feedback regulators in normal and tumour tissues.

B I Lord1

  • 1Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.

Journal of Cell Science. Supplement
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of stem cell cycling in mice increases their sensitivity to a chemical leukaemogen: implications for inherited genomic instability and the bystander effect.

Mutation research·2002
Same author

Bone marrow toxicity in mice treated with indium-114m-labelled blood cells.

Journal of experimental & clinical cancer research : CR·2002
Same author

Transgenerational effects of preconception paternal contamination with (55)Fe.

Radiation research·2001
Same author

Kinetics of neutrophil production in normal and neutropenic animals during the response to filgrastim (r-metHu G-CSF) or filgrastim SD/01 (PEG-r-metHu G-CSF).

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Tumorigenic target cell regions in bone marrow studied by localized dosimetry of 239Pu, 241Am and 233U in the mouse femur.

International journal of radiation biology·2001
Same author

Transgenerational susceptibility to leukaemia induction resulting from preconception, paternal irradiation.

International journal of radiation biology·2001
Same journal

Does the Wilms' tumour suppressor gene, WT1, play roles in both splicing and transcription?

Journal of cell science. Supplement·1995
Same journal

Regulation of transcription by E2F1/DP1.

Journal of cell science. Supplement·1995
Same journal

Regulation of cell proliferation and differentiation by Myc.

Journal of cell science. Supplement·1995
Same journal

Appearance of apparently ubiquitin-conjugated I kappa B-alpha during its phosphorylation-induced degradation in intact cells.

Journal of cell science. Supplement·1995
Same journal

Recognition and processing of damaged DNA.

Journal of cell science. Supplement·1995
Same journal

Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle.

Journal of cell science. Supplement·1995
See all related articles

Cell behavior and population size are regulated by negative feedback loops, similar to non-biological systems. Cancer cells often resist these feedback signals, offering potential therapeutic targets.

Area of Science:

  • Cell Biology
  • Biophysics
  • Cancer Research

Background:

  • Cellular regulation and population size control are often governed by negative feedback mechanisms, analogous to classical cybernetic principles.
  • These feedback loops can be direct, with products inhibiting progenitor cells, or indirect, involving complex inhibitor/stimulator interactions.
  • Understanding these regulatory pathways is crucial for comprehending normal development and disease states like cancer.

Purpose of the Study:

  • To explore the mechanisms of negative feedback regulation in cell behavior and population dynamics.
  • To investigate the role of feedback loops in hematopoietic development and cell cycle control.
  • To examine the implications of altered feedback sensitivity in tumor cells for cancer therapy.

Main Methods:

Related Experiment Videos

  • Analysis of feedback loop operations in various stages of hematopoietic development.
  • Investigation of inhibitor and stimulator effects on hematopoietic stem cells.
  • Characterization of feedback signals in normal and neoplastic cells, including tumor ascites and transforming growth factor-beta (TGF-β).

Main Results:

  • Hematopoietic stem cells are regulated by both direct inhibitors and stimulators, with feedback from the stem cell population influencing their production.
  • Maturing cells are subject to feedback inhibition from their mature descendants, modulating cell cycle progression.
  • Many tumor cells produce feedback signals but exhibit reduced sensitivity to them, and some are unable to activate latent growth factors like TGF-β.

Conclusions:

  • The cybernetic principle of negative feedback is fundamental to regulating cell behavior and population size.
  • Differential sensitivity of normal versus neoplastic tissues to physiological feedback regulators presents a promising avenue for cancer therapy.
  • Targeting these feedback mechanisms could offer novel therapeutic strategies for treating various cancers.