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Updated: Jul 30, 2026
12:19
Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Regulation of transcription by E2F1/DP1
K Martin1, D Trouche, C Hagemeier
1Wellcome/CRC Institute, University of Cambridge, UK.
Journal of Cell Science. Supplement
|January 1, 1995
Summary
The E2F1 transcription factor regulates cell cycle genes, driving S-phase. This review explores how protein interactions modulate E2F1
Area of Science:
- Molecular Biology
- Cell Cycle Regulation
- Transcription Factors
Background:
- The E2F1 transcription factor, partnered with DP1, governs the expression of S-phase specific genes.
- E2F1's activity is linked to its oncogenic and S-phase inducing properties, highlighting its critical role in cell cycle regulation.
Purpose of the Study:
- To review protein-protein interactions that regulate the E2F1 activation domain.
- To propose models for the mechanism of action of these regulatory interactions.
Main Methods:
- Literature review of studies on E2F1 and its interacting proteins.
- Analysis of existing data on transcriptional activation domains and protein binding.
Main Results:
- E2F1's transcriptional activation functions are localized to its C-terminal domain.
- Various protein-protein interactions modulate the activity of this C-terminal domain.
Conclusions:
- Protein interactions are crucial for regulating E2F1's function in cell cycle control.
- Understanding these interactions can provide insights into E2F1's role in oncogenesis.
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