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Quantification of Atherosclerosis in Mice
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Linking diabetes and atherosclerosis.

Riccardo Candido1, Stella Bernardi2, Terri J Allen3

  • 1a Diabetic Centre, Azienda per i Servizi Sanitari n. 1 "Triestina", Via Puccini 48/50, 34148 Trieste, Italy. riccardocandido@yahoo.it.

Expert Review of Endocrinology & Metabolism
|February 21, 2019
PubMed
Summary
This summary is machine-generated.

Diabetes accelerates atherosclerosis, leading to cardiovascular disease. Multifactorial treatments targeting conventional and emerging risk factors are crucial for preventing macrovascular complications in diabetic patients.

Keywords:
advance glycation end productsatherosclerosiscomplement systemdiabetesdiabetic dyslipidemiahypertensionimmunityinflammationrenin–angiotensin system

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Area of Science:

  • Cardiology
  • Endocrinology
  • Pathology

Background:

  • Cardiovascular diseases (CVDs) are primary causes of death in diabetic individuals.
  • Diabetes accelerates atherosclerosis (macroangiopathy), leading to widespread arterial disease.
  • Pathogenesis involves complex interactions of hyperglycemia, dyslipidemia, hypertension, and inflammation.

Purpose of the Study:

  • To review the causes and mechanisms of atherosclerotic disease in diabetes.
  • To highlight emerging therapeutic targets for macrovascular complications.

Main Methods:

  • Literature review focusing on diabetes-induced atherosclerosis.
  • Analysis of multifactorial pathogenesis and risk factors.
  • Identification of novel therapeutic targets.

Main Results:

  • Accelerated atherosclerosis in diabetes is driven by hyperglycemia, dyslipidemia, hypertension, endothelial dysfunction, and inflammation.
  • Emerging factors like AGE-RAGE axis, TRAIL, and complement system contribute.
  • Residual risk management beyond traditional factors is critical.

Conclusions:

  • A synergistic, multifactorial approach is essential for preventing macrovascular disease in diabetes.
  • Targeting both conventional and novel risk factors offers a promising therapeutic strategy.
  • Further research into emerging targets like AGE-RAGE, TRAIL, and complement is warranted.