Pharmacogenetics of osteoporosis

Osteoporosis is the most common and serious skeletal disorder of the elderly; it is characterized by reduced bone mass and deterioration of bone microarchitecture, with an increased risk of low-trauma fractures. Genetic factors are important predisposing elements influencing individual bone strength variability and susceptibility to osteoporosis and related complications. The genetics of osteoporosis encompasses two main areas: disease susceptibility and pharmacogenetics of drug response. The former has been widely studied while the latter is still largely untouched. Pharmacogenetics is the study of relationships between genetic variations and inter-individual differences in drug response in terms of efficacy and adverse effects, representing an opportunity to identify new biomarkers for drug development and drug response. However, pharmacogenetic approaches to osteoporosis are still in their infancy, needing to be developed further and combined with functional studies. This article provides an overview on the current basic research applications in the pharmacogenetics of osteoporosis and their implications for clinical practice.